merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1518,Anti-hnRNP L Antibody, clone 4D11

  • merck millipore,默克密理博,05-1518,Anti-hnRNP L Antibody, clone 4D11

    产品名称：Anti-hnRNP L Antibody, clone 4D11
    产品型号：05-1518
    Use Anti-hnRNP L Antibody, clone 4D11 (Mouse Monoclonal Antibody) validated in WB, IP to detect hnRNP L also known as heterogeneous nuclear ribonucleoprotein L.

    merck millipore,默克密理博,05-1518,Anti-hnRNP L Antibody, clone 4D11

  • 产品介绍
  • merck millipore,默克密理博,05-1518,Anti-hnRNP L Antibody, clone 4D11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1518
    描述 Anti-hnRNP L Antibody, clone 4D11
    Alternate Names
    • heterogeneous nuclear ribonucleoprotein L
    背景信息 Heterogeneous nuclear ribonucleoprotein L (HnRNP-L) is a polypyrimidine tract-binding protein (PTB)-binding protein and is commonly found in the nucleoplasm. HnRNP-L appears to be involved in transcription, pre-mRNA processing, mature mRNA transport to the cytoplasm, and translation. HnRNP-L binds to an RNA sequence element in a very sequence-specific manner that permit intron-independent gene expression.
    产品信息
    格式 Purified
    控制
    • HepG2 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-hnRNP L Antibody, clone 4D11 (Mouse Monoclonal Antibody) validated in WB, IP to detect hnRNP L also known as heterogeneous nuclear ribonucleoprotein L.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation:
    A representative lot detected hnRNP L in IP. (Topp, J.D., et al. (2008). RNA. 14:2038–2049.)
    生物信息
    免疫原品种 Human hnRNP proteins (from HeLa cells) purified by affinity chromatography on ssDNA agarose.
    克隆 4D11
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001005335
    Entrez基因汇总 Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
    基因符号
    • hnRNP L
    • HNRNPL
    • HNRPL
    纯化方法 Protein G
    UniProt编号
    • P14866
    UniProt汇总 FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.

    SUBUNIT STRUCTURE: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with HNRPLL.

    SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

    PTM: Several isoelectric forms of the L protein are probably the results of post-translational modifications.

    SEQUENCE SIMILARITIES: Contains 3 RRM (RNA recognition motif) domains.

    SEQUENCE CAUTION: The sequence CAA34261.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in HepG2 cell lysate.

    Western Blot Analysis: 0.01 µg/mL of this antibody detected hnRNP L on 10 µg of HepG2 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-1518,Anti-hnRNP L Antibody, clone 4D11

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