merck millipore,默克密理愽
  • merck millipore,默克密理博,14-624,MST1 Protein, active, 10 µg

  • merck millipore,默克密理博,14-624,MST1 Protein, active, 10 µg

    产品名称：MST1 Protein, active, 10 µg
    产品型号：14-624
    Active, N-terminal His6-tagged, recombinant, full-length, human MST1, for use in Kinase Assays.

    merck millipore,默克密理博,14-624,MST1 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-624,MST1 Protein, active, 10 µg

    描述
    产品目录编号 14-624
    品牌系列 Upstate
    商名
    • Upstate
    描述 MST1 Protein, active, 10 µg
    概述 N-terminal His6-tagged, recombinant, full-length, human MST1
    应用
    应用 Active, N-terminal His6-tagged, recombinant, full-length, human MST1, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_006282.2
    Entrez基因汇总 The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
    基因符号
    • YSK3
    • STK4
    • DKFZp686A2068
    • MST-1
    • MST1
    • KRS2
    蛋白靶 MST1
    纯化方法 Ni2+/NTA-agarose
    靶子系列 STE
    UniProt编号
    • Q13043
    UniProt汇总 FUNCTION: SwissProt: Q13043 # Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Phosphorylates 'Ser-14' of histone H2B during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
    COFACTOR: Magnesium.
    SIZE: 487 amino acids; 55630 Da
    SUBUNIT: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1, which leads to enzyme activation. Interacts with FOXO3.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
    TISSUE SPECIFICITY: Ubiquitously expressed.
    PTM: Autophosphorylated on serine and threonine residues.
    SIMILARITY: SwissProt: Q13043 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain. & Contains 1 SARAH domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of 250μM Axltide (KKSRGDYMTMQIG)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-624,MST1 Protein, active, 10 µg

上一件merck millipore产品：merck millipore,默克密理博,176908,Anthrax Protective Antigen, Bacillus anthracis, Nicked, Recombinant, B. anthracis - Calbiochem
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