merck millipore,默克密理博,04-1108,Anti-Vitronectin Antibody, clone EP873Y, rabbit monoclonal

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merck millipore,默克密理博,04-1108,Anti-Vitronectin Antibody, clone EP873Y, rabbit monoclonal
产品名称：Anti-Vitronectin Antibody, clone EP873Y, rabbit monoclonal
产品型号：04-1108
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Vitronectin Antibody, clone EP873Y, Rabbit More>>

merck millipore,默克密理博,04-1108,Anti-Vitronectin Antibody, clone EP873Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1108,Anti-Vitronectin Antibody, clone EP873Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	ICC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1108
描述	Anti-Vitronectin Antibody, clone EP873Y, rabbit monoclonal
Alternate Names	vitronectin (serum spreading factor, somatomedin B,<br />complement S-protein) Serum-spreading factor complement S-protein serum spreading factor somatomedin B
背景信息	Vitronectin (Serum Spreading Factor, Complement S-Protein) is a plasma protein and a component of the extracellular matrix in many tissues, where it promotes cell adhesion and spreading. Vitronectin also inhibits complement C5b-9-mediated cytolysis and regulates the action of thrombin. Vitronectin contains the cell binding sequence arg gly asp (RGD) and serves as a cell-to-substrate adhesion molecule, (Stefansson, 1996).

产品信息
格式	Unpurified
控制	Human serum membrane lysates
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Vitronectin Antibody, clone EP873Y, Rabbit is validated for use in IH(P), WB, IC for the detection of Vitronectin.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: 1:100-250 dilution from a previous lot detected Vitronectin in human liver tissue. Immunocytochemistry: 1:50-100 dilution from a previous lot was used in IC.

生物信息
免疫原品种	Synthetic peptide corresponding to residues near the V10 subunit of human vitronectin.
克隆	EP873Y
宿主	Rabbit
特异性	This antibody recognizes Vitronectin.
同种型	IgG
品种反应性	RatHumanMouse
Species Reactivity Note	Human, mouse, and rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	P04004
基因符号	vitronectin S-protein V75 VN VNT epibolin
纯化方法	Unpurified
UniProt编号	P04004
UniProt汇总	FUNCTION: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. SUBUNIT STRUCTURE: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin. SUBCELLULAR LOCATION: Secreted › extracellular space. TISSUE SPECIFICITY: Plasma. DOMAIN: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin. PTM: Sulfated on 2 tyrosine residues. N- and O-glycosylated By similarity. Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. SEQUENCE SIMILARITIES: Contains 4 hemopexin-like domains. Contains 1 SMB (somatomedin-B) domain.

产品使用声明
质量保证	Evaluated by Western Blot on human serum membrane lysate. Western Blot Analysis: 1:20,000 dilution of this antibody was used to detect Vitronectin in human serum membrane lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.