merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1584,Anti-Interleukin-2 (IL-2) Antibody, clone 3F9

  • merck millipore,默克密理博,04-1584,Anti-Interleukin-2 (IL-2) Antibody, clone 3F9

    产品名称：Anti-Interleukin-2 (IL-2) Antibody, clone 3F9
    产品型号：04-1584
    Detect Interleukin-2 (IL-2) using this Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 validated for use in WB.

    merck millipore,默克密理博,04-1584,Anti-Interleukin-2 (IL-2) Antibody, clone 3F9

  • 产品介绍
  • merck millipore,默克密理博,04-1584,Anti-Interleukin-2 (IL-2) Antibody, clone 3F9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-1584
    描述 Anti-Interleukin-2 (IL-2) Antibody, clone 3F9
    Alternate Names
    • T-cell growth factor
    • interleukin 2
    • involved in regulation of T-cell clonal expansion
    • aldesleukin
    • T cell growth factor
    • lymphokine
    • Aldesleukin
    • interleukin-2
    背景信息 Interleukin-2 (IL-2) is commonly considered a pro-inflammatory cytokine that stimulated T-cell-dependent immune reactions and control regulatory T cells or Tregs. Structurally, IL-2 is thought to have a 4-helix-bundle-type fold and uses a novel type I cytokine receptor (IL-21R) with the common gamma chain cytokine receptor. IL-2 also may intensify Th1-mediated diseases, including autoimmune arthritis and may also be interesting clinical targets for those diseases. IL-2 has also been implicated as a possible therapy for infection and cancer. Anti-tumor therapies that include a combination of recombinant IL-2 and recombinant interferon alpha have been promising in clinical studies.
    产品信息
    格式 Purified
    控制
    • Human IL-2 recombinant protein
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Interleukin-2 (IL-2) using this Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Full length recombinant protein corresponding to human IL-2.
    克隆 AB12.38.35C3.3F9
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000577
    Entrez基因汇总 The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq].
    基因符号
    • TCGF
    • IL2
    • IL-2
    纯化方法 Protein G Purified
    UniProt编号
    • P60568
    UniProt汇总 FUNCTION: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

    SUBCELLULAR LOCATION: Secreted.

    INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

    PHARMACEUTICAL USE: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

    SEQUENCE SIMILARITIES: Belongs to the IL-2 family.

    SEQUENCE CAUTION: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in lysate from cells expressing human IL-2 recombinant protein.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-2 recombinant protein.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-1584,Anti-Interleukin-2 (IL-2) Antibody, clone 3F9

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