merck millipore,默克密理愽
  • merck millipore,默克密理博,17-313,PP2A Immunoprecipitation Phosphatase Assay Kit

  • merck millipore,默克密理博,17-313,PP2A Immunoprecipitation Phosphatase Assay Kit

    产品名称：PP2A Immunoprecipitation Phosphatase Assay Kit
    产品型号：17-313
    PP2A Immunoprecipitation Phosphatase Assay Kit can be used to detect purified PP2A or PP2A from a cellular lysate. It utilizes the Malachite Green & contains components that have been matched to optim More>>

    merck millipore,默克密理博,17-313,PP2A Immunoprecipitation Phosphatase Assay Kit

  • 产品介绍
  • merck millipore,默克密理博,17-313,PP2A Immunoprecipitation Phosphatase Assay Kit

    重要规格表

    主要应用 可用的分析物
    PAPP2A
    描述
    产品目录编号 17-313
    品牌系列 Upstate
    商名
    • Upstate
    描述 PP2A Immunoprecipitation Phosphatase Assay Kit
    产品信息
    部件
    • 96-Well Microtiter Plate
    • Malachite Green Solution A (Cat.# 20-105)
    • Malachite Green Additive (Cat.# 20-104)
    • Phosphate Standard (Cat.# 20-103)
    • Threonine Phosphopeptide (K-R-pT-I-R-R) (Cat.# 12-219)
    • Anti-PP2A, C subunit, clone 1D6 (Cat.# 05-421)
    • pNPP Ser/Thr Assay Buffer (Cat.# 20-179)
    • Protein A Agarose
    应用
    应用 PP2A Immunoprecipitation Phosphatase Assay Kit can be used to detect purified PP2A or PP2A from a cellular lysate. It utilizes the Malachite Green & contains components that have been matched to optimize sensitivity & range of detection.
    主要应用
    • Phosphatase Assay
    生物信息
    可用的分析物
    • PP2A
    Entrez基因编号
    • NP_002706
    Entrez基因汇总 The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • RP-C
    • PPP2CA
    • PP2CA
    • PP2A-alpha
    • PP2Ac
    UniProt编号
    • P67775
    UniProt汇总 FUNCTION: SwissProt: P67775 # PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.
    COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
    SIZE: 309 amino acids; 35594 Da
    SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
    SUBCELLULAR LOCATION: Cytoplasm.
    PTM: Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. & Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
    SIMILARITY: SwissProt: P67775 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
    产品使用声明
    质量保证 Routinely evaluated by immunoprecipitation of purified PP2A (14-111) or PP2A from a cellular lysate. The activity is assessed by dephosphorylation of the phosphopeptide (K-R-pT-I-R-R).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 25 assays
    包装 Kit capacity: 25 assays

    merck millipore,默克密理博,17-313,PP2A Immunoprecipitation Phosphatase Assay Kit

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