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  • merck millipore,默克密理博,06-408,Anti-14-3-3 ζ/γ/η Antibody

  • merck millipore,默克密理博,06-408,Anti-14-3-3 ζ/γ/η Antibody

    产品名称：Anti-14-3-3 ζ/γ/η Antibody
    产品型号：06-408
    Detect 14-3-3 ζ/γ/η using this Anti-14-3-3 ζ/γ/η Antibody validated for use in WB.

    merck millipore,默克密理博,06-408,Anti-14-3-3 ζ/γ/η Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-408,Anti-14-3-3 ζ/γ/η Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    VrtWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 06-408
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-14-3-3 ζ/γ/η Antibody
    产品信息
    格式 Serum
    演示 rabbit antiserum
    应用
    应用 Detect 14-3-3 ζ/γ/η using this Anti-14-3-3 ζ/γ/η Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 HPLC-purified synthetic peptide (KMKGDYYRYLAE) corresponding to the zeta, gamma and eta isoforms of 14-3-3
    宿主 Rabbit
    特异性 zeta, gamma and eta isoforms of 14-3-3
    同种型 IgG
    品种反应性 Vertebrates
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003406
    Entrez基因汇总 This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.
    基因符号
    • MGC138156
    • YWHAZ
    • KCIP-1
    • MGC126532
    • MGC111427
    纯化方法 Antiserum
    UniProt编号
    • Q04917
    • P63104
    • P40763
    UniProt汇总 FUNCTION: SwissProt: P40763 # Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
    SIZE: 770 amino acids; 88068 Da
    SUBUNIT: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
    TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    PTM: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.
    DISEASE: "SwissProt: P40763 # Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures."
    SIMILARITY: SwissProt: P40763 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on a preparation of bovine brain cytosol
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 150 µL

    merck millipore,默克密理博,06-408,Anti-14-3-3 ζ/γ/η Antibody

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