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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-535 品牌系列 Upstate
商名 - Upstate
描述 Anti-MKP1 Antibody 产品信息 格式 Purified 控制 - Positive Control Included: 3T3 Cell Lysate (12-305)
演示 Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. 应用 应用 Detect MKP1 using this Anti-MKP1 Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 87-101 (DERSAALDGAKRDGT-C) of human MAP kinase phosphatase 1 (MKP1) 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes MKP1. 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004417
Entrez基因汇总 The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. 基因符号 - CL100
- DUSP1
- VH1
- YVH1
- HVH1
- MKP1
- MKP-1
- PTPN10
纯化方法 Protein A purfied UniProt编号 - P28562
UniProt汇总 FUNCTION: SwissProt: P28562 # Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'.
SIZE: 367 amino acids; 39298 Da
TISSUE SPECIFICITY: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
SIMILARITY: SwissProt: P28562 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 rhodanese domain. & Contains 1 tyrosine-protein phosphatase domain.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates from 3T3/A31 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
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