merck millipore,默克密理愽
  • merck millipore,默克密理博,14-552M,BTK Protein, active, 250 µg

  • merck millipore,默克密理博,14-552M,BTK Protein, active, 250 µg

    产品名称：BTK Protein, active, 250 µg
    产品型号：14-552M
    Active, N-terminal His6-tagged, recombinant, full-length, human BTK, for use in Kinase Assays.

    merck millipore,默克密理博,14-552M,BTK Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-552M,BTK Protein, active, 250 µg

    描述
    产品目录编号 14-552M
    品牌系列 Upstate
    商名
    • Upstate
    描述 BTK Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant, full-length, human BTK
    应用
    应用 Active, N-terminal His6-tagged, recombinant, full-length, human BTK, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_000061.1
    Entrez基因汇总 Defects in the Bruton tyrosine kinase (BTK) gene cause Agammaglobulinemia. Agammaglobulinemia is an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement.
    基因符号
    • AGMX1
    • BTK
    • PSCTK1
    • MGC126261
    • ATK
    • XLA
    • IMD1
    • AT
    • OTTHUMP00000063593
    • BPK
    • MGC126262
    蛋白靶 BTK
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • Q06187
    UniProt汇总 FUNCTION: SwissProt: Q06187 # Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.
    COFACTOR: Binds 1 zinc ion per subunit.
    SIZE: 659 amino acids; 76281 Da
    SUBUNIT: Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with GTF2I and ARID3A.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity).
    PTM: Autophosphorylated on Tyr-223 and Tyr-551. Phosphorylation of Tyr-223 may create a docking site for a SH2 containing protein (By similarity).
    DISEASE: SwissProt: Q06187 # Defects in BTK are the cause of X-linked agammaglobulinemia type 1 (XLA) [MIM:300300]. XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis in the first few years of life, or even some patients present overwhelming sepsis or meningitis, resulting in death in a few hours. Treatment in most cases is by infusion of intravenous immunoglobulin. & Defects in BTK may be the cause of X-linked hypogammaglobulinemia and isolated growth hormone deficiency (XLA- IGHD) [MIM:307200]; also known as agammaglobulinemia and isolated growth hormone deficiency or Fleisher syndrome or isolated growth hormone deficiency type 3 (IGHD3). In rare cases XLA is inherited together with isolated growth hormone deficiency (IGHD).
    SIMILARITY: SwissProt: Q06187 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Src substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-552) and in bulk (cat# 14-552-K).

    merck millipore,默克密理博,14-552M,BTK Protein, active, 250 µg

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