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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, R, Rhesus Macaque WB Rb Purified Polyclonal Antibody 描述 产品目录编号 ABC157 Replaces MABE188 描述 Anti-MCM7 Antibody Alternate Names - P1.1-MCM3
- DNA replication licensing factor MCM7
- CDC47 homolog
背景信息 MCM7 is a highly conserved mini-chromosome maintenance protein (MCM) that is involved in the initiation of eukaryotic genome replication. It forms a hexameric complex with MCM4 and MCM6 (two subunits of MCM7, two subunits of MCM4 and two subunits of MCM7) and this complex regulates the helicase activity of the pre-replication complex. This complex is also involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. MCM7 is reported to bind to DNA in metaphase II in oocytes and remains associated with the DNA until the S-phase. Two isoforms of MCM7 have been reported, 61 kDa and 90 kDa. In neuroblastoma tumors MCM7 expression is shown to correlates with MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived) amplification where in MCM7 is rapidly up-regulated by Inducible MYCN Expression. MYCN protein is shown to bind specifically to the MCM7 promoter region, which possesses an E-box binding site for the Myc oncoproteins. 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This MCM7 antibody is validated for use in WB for the detection of the MCM7 protein. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 0.5 µg/mL from a representative lot detected MCM7 in 10 µg of L6 cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the N-terminus of human MCM7. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the N-terminus of MCM7 品种反应性 ChimpanzeeHumanRatRhesus Macaque Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Rhesus Macaque and Chimpanzee based on 100% sequence homology. Other homologies: Mouse (71% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005907
基因符号 - MCM2
- MCM7
- CDC47
纯化方法 Protein A purified UniProt编号 - P33993
产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected MCM7 in 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,ABN498,Anti-MYH11 Antibody
下一件merck millipore产品：merck millipore,默克密理博,06-408,Anti-14-3-3 ζ/γ/η Antibody
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