merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3898,Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear

  • merck millipore,默克密理博,AB3898,Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear

    产品名称：Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear
    产品型号：AB3898
    Detect c-abl Tyrosine Kinase using this Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear validated for use in WB.

    merck millipore,默克密理博,AB3898,Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear

  • 产品介绍
  • merck millipore,默克密理博,AB3898,Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3898
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear
    Alternate Names
    • JTK7
    • p150
    • Abl
    产品信息
    格式 Purified
    演示 Protein A purified immunoglobulin. Liquid in 0.02 M phosphate buffer with 0.15 M NaCl, pH 7.6 and 0.1% sodium azide as a preservative.
    应用
    应用 Detect c-abl Tyrosine Kinase using this Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000 (1.0μg/mL).

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant human GST-Abl fusion protein.
    表位 cytoplasmic & nuclear
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes human Abl. The c-Abl protein is a widely expressed non-receptor tyrosine kinase that is involved in processes of cell differentiation, cell division, cell adhesion, and stress response. This antibody detects an ~120 kDa band, corresponding to the expected molecular weight of human Abl.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_007313.2
    • NM_005157.3
    Entrez基因汇总 The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
    基因符号
    • EC 2.7.10.2
    • ABL1
    • JTK7
    • p150
    • bcr/abl
    • v-abl
    • c-ABL
    • ABL
    UniProt编号
    • P00519
    UniProt汇总 FUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
    COFACTOR: Magnesium or manganese.
    SIZE: 1130 amino acids; 122873 Da
    SUBUNIT: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
    TISSUE SPECIFICITY: Widely expressed.
    PTM: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.
    DISEASE: SwissProt: P00519 # A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
    SIMILARITY: SwissProt: P00519 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB3898,Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear

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