merck millipore,默克密理愽
  • merck millipore,默克密理博,287840,Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

  • merck millipore,默克密理博,287840,Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

    产品名称：Diclofenac Sodium - CAS 15307-79-6 - Calbiochem
    产品型号：287840
    A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

    merck millipore,默克密理博,287840,Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,287840,Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₀Cl₂NO₂ · Na15307-79-6
    描述
    概述 A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
    产品目录编号 287840
    品牌系列 Calbiochem®
    同义词 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
    参考
    参考 Kato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
    Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
    Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
    Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
    Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
    Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
    产品信息
    CAS号 15307-79-6
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₄H₁₀Cl₂NO₂ · Na
    化学配方 C₁₄H₁₀Cl₂NO₂ · Na
    Molar Mass 318.1
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 COX-1
    主靶IC50 60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity
    纯度 ≥98% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    GHS安全信息
    RTECS AG6330000
    安全信息
    R相 R: 23/24/25-63

    Toxic by inhalation, in contact with skin and if swallowed.
    Possible risk of harm to the unborn child.
    S相 S: 22-36

    Do not breathe dust.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Toxic & Carcinogenic / Teratogenic
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 +15°C to +30°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,287840,Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

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