merck millipore,默克密理愽
  • merck millipore,默克密理博,16-246,Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488

  • merck millipore,默克密理博,16-246,Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488

    产品名称：Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488
    产品型号：16-246
    This Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488 is validated for use in IF for the detection of EGFR.

    merck millipore,默克密理博,16-246,Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488

  • 产品介绍
  • merck millipore,默克密理博,16-246,Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIFMAlexaFluor®488Monoclonal Antibody
    描述
    产品目录编号 16-246
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor® 488
    概述 Included Negative Control: Catalog # 16-240, Alexa Fluor® 488-conjugated Normal Mouse IgG.

    Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor.
    产品信息
    格式 AlexaFluor®488
    应用
    应用 This Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488 is validated for use in IF for the detection of EGFR.
    主要应用
    • Immunofluorescence
    生物信息
    免疫原品种 Human A431 membrane proteins
    克隆 clone LA1
    宿主 Mouse
    特异性 external domain of EGF receptor on all human cells. Competes with EGF and TGF-α for binding on human cells. Recognizes both phosphorylated and non-phosphorylated human EGF receptors.
    同种型 IgG1
    品种反应性 Human
    Species Reactivity Note Does not react with EGF receptors on mouse or rat cells.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_201284.1
    • NM_005228.3
    • NM_201282.1
    • NM_201283.1
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
    SIZE: 1210 amino acids; 134277 Da
    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
    产品使用声明
    质量保证 Routinely evaluated by positive immunostaining for the EGF receptor in A431 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
    储存和货运信息
    存储条件 1 year at 4°C from date of shipment
    包装信息
    数量 125 µg

    merck millipore,默克密理博,16-246,Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488

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