merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1847,Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

  • merck millipore,默克密理博,AB1847,Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

    产品名称：Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop
    产品型号：AB1847
    Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop detects level of C-X-C Chemokine Receptor 4 & has been published & validated for use in WB.

    merck millipore,默克密理博,AB1847,Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

  • 产品介绍
  • merck millipore,默克密理博,AB1847,Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1847
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop
    Alternate Names
    • CXCR4
    • CD184
    产品信息
    格式 Purified
    演示 Purified IgG in PBS containing 0.02% sodium azide.
    应用
    应用 Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop detects level of C-X-C Chemokine Receptor 4 & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:500 - 1000

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Extracellular loop peptide of human CXCR4 (Berson et al. 1996; Leotscher et al. 1994).
    表位 extracellular loop
    宿主 Rabbit
    特异性 Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (Nimitrov 1997). Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principle coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells (Feng et al. 1996; Berson et al. 1996). CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2 (Doranz et al. 1996; Endres et al. 1996). The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1 (Bleul et al. 1996; Oberlin et al. 1996). CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells (Lapham et al. 1996). CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types (Feng et al. 1996). Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells (Feng et al. 1996; Endres et al. 1996; Brelot et al. 1997). The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites (Brelot et al. 1997; Lu et al. 1997).
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003467.2
    • NM_001008540.1
    Entrez基因汇总 This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    基因符号
    • LESTR
    • CXCR4
    • WHIM
    • NPY3R
    • NPYY3R
    • FB22
    • LAP3
    • Fusin
    • CXCR-4
    • LCR1
    • NPYR
    • HM89
    • fusin
    • HSY3RR
    • CXC-R4
    • NPYY3
    • NPYRL
    • D2S201E
    • CD184
    UniProt编号
    • P61073
    UniProt汇总 FUNCTION: SwissProt: P61073 # Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
    SIZE: 352 amino acids; 39746 Da
    SUBUNIT: Interacts with HIV-1 surface protein gp120 and Tat.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
    DOMAIN: SwissProt: P61073 The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.
    PTM: Sulfated.
    DISEASE: SwissProt: P61073 # Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts, hypogammaglobulinemia, infections, and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.
    SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Can be refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB1847,Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

上一件merck millipore产品：merck millipore,默克密理博,MABC140,Anti-ARC Antibody, clone 6F9.1
下一件merck millipore产品：merck millipore,默克密理博,FCABS326PE,Milli-Mark Anti-acetyl-Histone H4 Antibody-PE


相关产品

merck millipore,默克密理博,9024-HK,Canine C-Peptide RIA merck millipore,默克密理博,9024-HK,Canine C-Peptide RIA

merck millipore,默克密理博,CC115,Chicken Tenascin merck millipore,默克密理博,CC115,Chicken Tenascin

merck millipore,默克密理博,21538,IHC Select Secondary Goat Anti-Mouse IgG Antibody, prediluted, biotinylated merck millipore,默克密理博,21538,IHC Select Secondary Goat Anti-Mouse IgG Antibody, prediluted, biotinylated

merck millipore,默克密理博,MERS00002,Millicell-ERS 电压电阻表 merck millipore,默克密理博,MERS00002,Millicell-ERS 电压电阻表

merck millipore,默克密理博,MABC140,Anti-ARC Antibody, clone 6F9.1 merck millipore,默克密理博,MABC140,Anti-ARC Antibody, clone 6F9.1

merck millipore,默克密理博,FCABS326PE,Milli-Mark Anti-acetyl-Histone H4 Antibody-PE merck millipore,默克密理博,FCABS326PE,Milli-Mark Anti-acetyl-Histone H4 Antibody-PE

merck millipore,默克密理博,HTS210RTA,Ready-to-Assay™ P2Y2 Purinergic Receptor Frozen Cells merck millipore,默克密理博,HTS210RTA,Ready-to-Assay™ P2Y2 Purinergic Receptor Frozen Cells

merck millipore,默克密理博,09-821,Anti-KLF4 Antibody merck millipore,默克密理博,09-821,Anti-KLF4 Antibody

merck millipore,默克密理博,311155,Dansyl Chloride - CAS 605-65-2 - Calbiochem merck millipore,默克密理博,311155,Dansyl Chloride - CAS 605-65-2 - Calbiochem

merck millipore,默克密理博,16-246,Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488 merck millipore,默克密理博,16-246,Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部