merck millipore,默克密理愽
  • merck millipore,默克密理博,14-784,mTOR Protein and FKBP12 Protein, 1 kit

  • merck millipore,默克密理博,14-784,mTOR Protein and FKBP12 Protein, 1 kit

    产品名称：mTOR Protein and FKBP12 Protein, 1 kit
    产品型号：14-784
    This product includes 10 µg of active mTOR & 1 mg of FKBP12 (mTOR: N-terminal FLAG-tagged, recombinant, human, amino acids 1362-end. FKBP12: N-terminal 6His-tagged recombinant, human, full length).

    merck millipore,默克密理博,14-784,mTOR Protein and FKBP12 Protein, 1 kit

  • 产品介绍
  • merck millipore,默克密理博,14-784,mTOR Protein and FKBP12 Protein, 1 kit

    描述
    产品目录编号 14-784
    品牌系列 Upstate
    商名
    • Upstate
    描述 mTOR Protein and FKBP12 Protein, 1 kit
    概述 This product includes 10 µg of active mTOR (1362-end) and 1 mg of FKBP12.
    背景信息 FKBP12: N-terminal 6His-tagged recombinant, full length, human FKBP12, expressed in E.coli.

    mTOR (1362-end), active: N-terminal FLAG™-tagged, recombinant, human mTOR, amino acids 1362-end, expressed by baculovirus in Sf21 insect cells.
    产品信息
    部件
    • FKBP12
    • mTOR (1362-end), active (Cat.# 14-770)
    演示 mTOR Enzyme in 10mM HEPES, 50mM NaCl, 50mM β-glycerophosphate, 0.25 mM sodium orthovanadate, 10 mM NaF, 300 μg/ml FLAG™ peptide, 20% v/v glycerol.

    FKBP12in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij 35, 270mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
    应用
    应用 This product includes 10 µg of active mTOR & 1 mg of FKBP12 (mTOR: N-terminal FLAG-tagged, recombinant, human, amino acids 1362-end. FKBP12: N-terminal 6His-tagged recombinant, human, full length).
    生物信息
    品种 Human
    Entrez基因编号
    • NM_004958.2
    Entrez基因汇总 The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene.
    基因符号
    • RAFT1
    • FRAP1
    • RAPT1
    • MTOR
    • FRAP
    • mTOR
    • FLJ44809
    • FRAP2
    蛋白靶 mTOR (FRAP1)
    靶子系列 Lipid/Atypical
    UniProt编号
    • P42345
    UniProt汇总 FUNCTION: SwissProt: P42345 # Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
    SIZE: 2549 amino acids; 288892 Da
    SUBUNIT: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.
    TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in testis.
    SIMILARITY: SwissProt: P42345 ## Belongs to the PI3/PI4-kinase family. & Contains 1 FAT domain. & Contains 1 FATC domain. & Contains 7 HEAT repeats. & Contains 1 PI3K/PI4K domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store -70°C
    包装信息
    数量 1 kit

    merck millipore,默克密理博,14-784,mTOR Protein and FKBP12 Protein, 1 kit

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