merck millipore,默克密理博,559389,SB 203580 - CAS 152121-47-6

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merck millipore,默克密理博,559389,SB 203580 - CAS 152121-47-6 - Calbiochem
产品名称：SB 203580 - CAS 152121-47-6 - Calbiochem
产品型号：559389
A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

merck millipore,默克密理博,559389,SB 203580 - CAS 152121-47-6 - Calbiochem

产品介绍

merck millipore,默克密理博,559389,SB 203580 - CAS 152121-47-6 - Calbiochem

重要规格表

经验配方	CAS号
C₂₁H₁₆N₃OSF	152121-47-6

描述
概述	Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC₅₀ = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC₅₀ = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
产品目录编号	559389
品牌系列	Calbiochem®
同义词	4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI

参考
参考	Yamada. T., et al. 2012. Free Radic. Biol. Med. (In press) Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. LoGrasso, P.V., et al. 1997. Biochem. 36, 10422. Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586. Cuenda, A., et al. 1995. FEBS Lett. 364, 229. Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171. Lee, J.C., et al. 1994. Nature 372, 739.

参考

Yamada. T., et al. 2012. Free Radic. Biol. Med. (In press)
Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Davies, S.P., et al. 2000. Biochem. J. 351, 95.
Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028.
Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586.
Cuenda, A., et al. 1995. FEBS Lett. 364, 229.
Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171.
Lee, J.C., et al. 1994. Nature 372, 739.

产品信息
CAS号	152121-47-6
具有ATP竞争性	Y
形式	Thin film
Hill配方	C₂₁H₁₆N₃OSF
化学配方	C₂₁H₁₆N₃OSF
Molar Mass	377.4
可逆	Y
结构配方图像

生物信息
主靶	P38MAPK
主靶IC₅₀	34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.