merck millipore,默克密理愽
  • merck millipore,默克密理博,14-638,MLCK Protein, active, 10 µg

  • merck millipore,默克密理博,14-638,MLCK Protein, active, 10 µg

    产品名称：MLCK Protein, active, 10 µg
    产品型号：14-638
    Active, N-terminal 6His-tagged, recombinant, human MLCK, amino acids 1425-1771, for use in Kinase Assays.

    merck millipore,默克密理博,14-638,MLCK Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-638,MLCK Protein, active, 10 µg

    描述
    产品目录编号 14-638
    品牌系列 Upstate
    商名
    • Upstate
    描述 MLCK Protein, active, 10 µg
    概述 N-terminal 6His-tagged, recombinant, human MLCK, amino acids 1425-1771
    应用
    应用 Active, N-terminal 6His-tagged, recombinant, human MLCK, amino acids 1425-1771, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_053032.2
    • NM_005965.3
    • NM_053029.2
    • NM_053030.2
    • NM_053025.3
    • NM_053026.3
    • NM_053027.3
    • NM_053028.3
    • NM_053031.2
    Entrez基因汇总 This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
    基因符号
    • Telokin
    • MYLK
    • DKFZp686I10125
    • MLCK108
    • FLJ12216
    • MSTP083
    • KRP
    • MLCK210
    • MLCK
    蛋白靶 MLCK
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CAMK
    UniProt编号
    • Q15746
    UniProt汇总 FUNCTION: SwissProt: Q15746 # Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Implicated in the regulation of endothelial as well as vascular permeability. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis.
    COFACTOR: Magnesium. & Calcium.
    SIZE: 1914 amino acids; 210774 Da
    SUBUNIT: All isoforms including Telokin bind calmodulin.
    TISSUE SPECIFICITY: Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues.
    PTM: MLCK is probably down-regulated by phosphorylation.
    SIMILARITY: SwissProt: Q15746 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 fibronectin type-III domain. & Contains 9 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of ZIPtide (Catalog # 12-545)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C from date of shipment
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-638,MLCK Protein, active, 10 µg

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