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描述 产品目录编号 14-335 品牌系列 Upstate
商名 - Upstate
描述 PRAK Protein, unactive, 50 µg 概述 Recombinant full-length human PRAK with an N-terminal His-tag 应用 应用 unactive, recombinant full-length human PRAK with an N-terminal His-tag, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in Sf9 cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_139078.1
- NM_003668.2
Entrez基因汇总 The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. 基因符号 - PRAK
- MAPKAPK5
蛋白靶 PRAK 纯化方法 Ni-NTA agarose 靶子系列 CAMK UniProt编号 - Q8IW41
UniProt汇总 FUNCTION: SwissProt: Q8IW41 # Mediates stress-induced small heat shock protein 27 phosphorylation.
SIZE: 473 amino acids; 54220 Da
SUBUNIT: Interacts with SQSTM1.
SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus. Note=Also observed in the nucleus.
TISSUE SPECIFICITY: Expressed ubiquitously.
PTM: Phosphorylated on Thr-182; which is the regulatory phosphorylation site and is located on the T-loop/loop 12.
SIMILARITY: SwissProt: Q8IW41 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of PRAK Substrate Peptide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 6 months at -20C 包装信息 数量 1 mg
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