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merck millipore,默克密理博,04-406,Anti-PKCβII Antibody, rabbit monoclonal
产品名称：Anti-PKCβII Antibody, rabbit monoclonal
产品型号：04-406
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-PKCβII Antibody, rabbit is validated for u More>>
merck millipore,默克密理博,04-406,Anti-PKCβII Antibody, rabbit monoclonal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, FC Rb Purified Monoclonal Antibody 描述 产品目录编号 04-406 品牌系列 Upstate
商名 - Upstate
描述 Anti-PKCβII Antibody, rabbit monoclonal Alternate Names - Protein Kinase C
产品信息 格式 Purified 演示 100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol. 应用 应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-PKCβII Antibody, rabbit is validated for use in FC, IF, IP, WB, IH(P) for the detection of PKCβII. 主要应用 - Western Blotting
- Flow Cytometry
生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to a region in the C-terminus of human PKCβII. 宿主 Rabbit 特异性 Recognizes the C-terminus of PKCβII. It does not cross-react with the closely related PKCβI isoform. 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_212535.1
- NM_002738.5
Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. 基因符号 - PKC-beta
- PRKCB1
- PRKCB
- PRKCB2
- PKCB
- MGC41878
- PKC-B
UniProt编号 - P05771
UniProt汇总 FUNCTION: SwissProt: P05771 # This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity).
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
SIZE: 671 amino acids; 76869 Da
SUBUNIT: Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
PTM: Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly, isoform beta-II is autophosphorylated on 'Thr-640' and 'Ser-659', subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i.e. in the N-terminal and hinge regions have no effect on PKC activity (By similarity).
SIMILARITY: SwissProt: P05771 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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