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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Gt Purified Polyclonal Antibody 描述 产品目录编号 07-226 品牌系列 Upstate
商名 - Upstate
描述 Anti-TrkC Antibody 产品信息 格式 Purified 应用 应用 Detect TrkC using this Anti-TrkC Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Extracellular domain of rat TrkC receptor, corresponding to amino acid residues 1-429 宿主 Goat 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_019248
Entrez基因汇总 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. 基因符号 - GP145-TrkC
- NTRK3
- TRKC
- Trk-C
- gp145(trkC)
纯化方法 Protein G chromatography UniProt编号 - Q16288
UniProt汇总 FUNCTION: SwissProt: Q16288 # Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
SIZE: 839 amino acids; 94428 Da
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.
PTM: Ligand-mediated auto-phosphorylation.
SIMILARITY: SwissProt: Q16288 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 200 µg
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