merck millipore,默克密理博,06-900,Anti-SynGAP Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R	WB, ICC	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	06-900
Replaces	04-1071
品牌系列	Upstate
商名	Upstate
描述	Anti-SynGAP Antibody
背景信息	Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

产品信息
格式	Purified
演示	Purified in PBS with 0.05% NaN3 and 30% Glycerol

应用
应用	Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
主要应用	Western Blotting Immunocytochemistry
应用说明	Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).

生物信息
免疫原品种	peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a
宿主	Rabbit
特异性	SynGAP
品种反应性	Rat
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_006772.1
基因符号	KIAA1938 SYNGAP1 RASA5 DKFZp761G1421 OTTHUMP00000064825 SYNGAP RASA1
纯化方法	Protein A purfied
UniProt编号	Q96PV0
UniProt汇总	FUNCTION: SwissProt: Q96PV0 # Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). SIZE: 1343 amino acids; 148284 Da SUBUNIT: Interacts CAMK2A and CAMK2B (By similarity). Interacts with MPDZ. PTM: Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption (By similarity). SIMILARITY: SwissProt: Q96PV0 ## Contains 1 C2 domain. & Contains 1 PH domain. & Contains 1 Ras-GAP domain.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

包装信息
数量	1

merck millipore,默克密理博,06-900,Anti-SynGAP Antibody

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