merck millipore,默克密理愽
  • merck millipore,默克密理博,129874,Amifostine - CAS 20537-88-6 - Calbiochem

  • merck millipore,默克密理博,129874,Amifostine - CAS 20537-88-6 - Calbiochem

    产品名称：Amifostine - CAS 20537-88-6 - Calbiochem
    产品型号：129874
    A cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs.

    merck millipore,默克密理博,129874,Amifostine - CAS 20537-88-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,129874,Amifostine - CAS 20537-88-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₅H₁₅N₂O₃PS •3H₂O20537-88-6
    描述
    概述 A cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
    产品目录编号 129874
    品牌系列 Calbiochem®
    同义词 2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
    参考
    参考 Dedieu, S., et al. 2010. BMC Medicine 8, 19.
    Yoon, Y.D., et al. 2005. In Vivo 19, 509.
    Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
    Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
    产品信息
    CAS号 20537-88-6
    形式 Off-white solid
    Hill配方 C₅H₁₅N₂O₃PS •3H₂O
    化学配方 C₅H₁₅N₂O₃PS •3H₂O
    Molar Mass 268.3
    结构配方图像
    生物信息
    纯度 ≥99% by NMR
    理化信息
    溶解度 H₂O
    安全信息
    R相 R: 22

    Harmful if swallowed.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    防潮 Protect from moisture
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,129874,Amifostine - CAS 20537-88-6 - Calbiochem

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