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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15242 描述 Anti-zDHHC8 Antibody Alternate Names - zinc finger, DHHC-type containing 8
- Zinc finger DHHC domain-containing protein 8
- Zinc finger protein 378
- membrane-associated DHHC8 zinc finger protein
- zinc finger, DHHC domain containing 8
- zinc finger, DHHC domain like containing 1
- DHHC domain like containing 1
背景信息 Six genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome–Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode mitochondrial proteins. All six genes are expressed in the
brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).
产品信息 格式 Affinity Purified 控制 - Fetal human brain
演示 Purified in PBS with 0.05% NaN3 应用 应用 Anti-zDHHC8 Antibody is an antibody against zDHHC8 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Syntheic linear peptide. 表位 C-Terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Cat. AB15242 recognizes the C-terminus of zDHHC8. 品种反应性 RatHuman Species Reactivity Note Human and Rat. Predicted to react with horse, pig, opposum, mouse, cow, xenopus, chimp ,chicken, dog, ape. 抗体类型 Polyclonal Antibody Entrez基因编号 - Q9ULC8
基因符号 - ZNF378
- DHHC-8
- EC 2.3.1.-
- KIAA1292
- ZDHHCL1
纯化方法 Immunoaffinity purified UniProt编号 - Q9ULC8
UniProt汇总 FUNCTION: Putative palmitoyltransferase involved in glutamatergic transmission By similarity.
Catalytic activity Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR:Cytoplasmic vesicle membrane; Multi-pass membrane proteinPotential.
DOMAIN: The DHHC domain is required for palmitoyltransferase activity By similarity.
DISEASE: According to Ref.6 and Ref.7, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to Ref.8, Ref.9 and Ref.10, it is not the case.
SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Contains 1 DHHC-type zinc finger.
产品使用声明 质量保证 Routinely evaluated by western blot in fetal human brain lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
包装信息 数量 100 µg
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