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merck millipore,默克密理博,217692,CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
产品名称：CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
产品型号：217692
The CDC25 Phosphatase Inhibitor II, NSC 663284, also referenced under CAS 383907-43-5, controls the biological activity of CDC25 Phosphatase. This small molecule/inhibitor is primarily used for Phosph More>>
merck millipore,默克密理博,217692,CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,217692,CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
重要规格表
经验配方 CAS号 C₁₅H₁₆ClN₃O₃ 383907-43-5 描述 概述 A cell-permeable 7-substituted quinolinedione compound that displays antiproliferative properties. Acts as a potent, irreversible and mixed competitive inhibitor of the CDC25 phosphatase family (Ki = 29 nM, 95 nM and 89 nM for CDC25A, CDC25B2 and CDC25C, respectively; IC50 = 210 nM for CDC25B2) and displays nearly 20- and 450-fold greater selectivity for the CDC252 phosphatases over VHR and PTP1B (IC50 = 4.0 µM and > 100 µM, respectively). Reported to arrest cell cycle progression, inhibit Cdk dephosphorylation and delay tumor growth (IC50 = ~1.5 µM in NCI-60 tumor cell panel). Shown to modify CDC25A catalytic domain and to block cellular ERK dephosphorylation in HeLa-CDC25A cells. 产品目录编号 217692 品牌系列 Calbiochem®
同义词 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione, DA3003-1, PTP Inhibitor XXI, VHR Inhibitor II 参考 参考 Chao, J. I., et al. 2004. J. Biol. Chem. 279, 20267.
Han, Y., et al. 2004. J. Pharmacol. Exp. Ther. 309, 64.
Pu, L., et al. 2002. J. Biol. Chem. 277, 46877.
Lazo, J.S., et al. 2001. J. Med. Chem. 44, 4042.产品信息 CAS号 383907-43-5 具有ATP竞争性 N 形式 Red solid Hill配方 C₁₅H₁₆ClN₃O₃ 化学配方 C₁₅H₁₆ClN₃O₃ Molar Mass 321.8 可逆 N 结构配方图像 生物信息 主靶 CD25A 主靶Ki 29 nM, 95 nM and 89 nM for CDC25A, CDC25B2 and CDC25C, respectively; 210 nM for CDC25B2 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Ethanol stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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