merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3226,Anti-Cytokeratin 7 Antibody, clone RCK105

  • merck millipore,默克密理博,MAB3226,Anti-Cytokeratin 7 Antibody, clone RCK105

    产品名称：Anti-Cytokeratin 7 Antibody, clone RCK105
    产品型号：MAB3226
    Anti-Cytokeratin 7 Antibody, clone RCK105 is an antibody against Cytokeratin 7 for use in FC, WB, IC, IH.

    merck millipore,默克密理博,MAB3226,Anti-Cytokeratin 7 Antibody, clone RCK105

  • 产品介绍
  • merck millipore,默克密理博,MAB3226,Anti-Cytokeratin 7 Antibody, clone RCK105

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Fe, Ca, H, Ht, M, Po, RIHC, FC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3226
    Replaces MABT150
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cytokeratin 7 Antibody, clone RCK105
    背景信息 Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight from between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8, The individual cytokeratin polypeptides are designated 1-20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies.
    产品信息
    格式 Purified
    演示 Liquid in buffer with 0.1% sodium azide.
    应用
    应用 Anti-Cytokeratin 7 Antibody, clone RCK105 is an antibody against Cytokeratin 7 for use in FC, WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blot: 57-58kDa band in reduce westerns

    Immunohistochemistry on frozen tissue sections.

    Immunocytochemistry

    Flow cytometry

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Cytokeratins from the human bladder carcinoma cell line T24.
    克隆 RCK105
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 MAB3226 reacts with a subgroup of glandular epithelial and their tumors, as well as transitional epithelium and transitional carcinoma. It reacts with a 58 kDa protein corresponding to cytokeratin 7.
    同种型 IgG1
    品种反应性 FelineCanineHumanHamsterMousePigRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_019010.1
    Entrez基因汇总 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.
    基因符号
    • MGC35423
    • KRT20
    • K20
    • CK20
    • Keratin-20
    • CK-20
    • KRT21
    • Cytokeratin-20
    • CD20
    UniProt编号
    • P35900
    UniProt汇总 FUNCTION: SwissProt: P35900 # Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
    SIZE: 424 amino acids; 48487 Da
    SUBUNIT: Heterotetramer of two type I and two type II keratins. Associates with KRT8.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa,and in the taste buds of lingual mucosa.
    DEVELOPMENTAL STAGE: First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low- differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.
    PTM: Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity). & Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
    SIMILARITY: SwissProt: P35900 ## Belongs to the intermediate filament family.
    MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3226,Anti-Cytokeratin 7 Antibody, clone RCK105

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