merck millipore,默克密理愽
  • merck millipore,默克密理博,124030,Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem

  • merck millipore,默克密理博,124030,Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem

    产品名称：Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem
    产品型号：124030
    The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,124030,Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124030,Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem

    重要规格表

    经验配方
    C₄₀H₄₃N₇O₂ • 3HCl
    描述
    概述 A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC50 = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and > 10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC50 > 50 µM). One of its potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.
    产品目录编号 124030
    品牌系列 Calbiochem®
    同义词 N-(2-(Diethylamino)ethyl)-3-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinolinecarboxamide, 3HCl, N-(2-(Diethylamino)ethyl)-2-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinolinecarboxamide, 3HCl and
    参考
    参考 Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett. 18, 49.
    产品信息
    形式 Yellow solid
    Hill配方 C₄₀H₄₃N₇O₂ • 3HCl
    化学配方 C₄₀H₄₃N₇O₂ • 3HCl
    Molar Mass 763.2
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC (mixture of regioisomers)
    理化信息
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124030,Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 - Calbiochem

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