merck millipore,默克密理愽
  • merck millipore,默克密理博,124037,Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

  • merck millipore,默克密理博,124037,Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

    产品名称：Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem
    产品型号：124037
    The Akt Inhibitor XIX, 3CAI, also referenced under CAS 28755-03-5, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl More>>

    merck millipore,默克密理博,124037,Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124037,Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₈ClNO28755-03-5
    描述
    概述 A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50 = 30 mg/kg; 5 times/wk for 3 wks via p.o.) in vivo.
    产品目录编号 124037
    品牌系列 Calbiochem®
    同义词 3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone
    参考
    参考 Kim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.
    产品信息
    CAS号 28755-03-5
    形式 Pink solid
    Hill配方 C₁₀H₈ClNO
    化学配方 C₁₀H₈ClNO
    Molar Mass 193.6
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    防潮 Protect from moisture
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124037,Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,MABN1084,Anti-IL-12 alpha, clone EP5737, Rabbit Monoclonal Antibody
下一件merck millipore产品：merck millipore,默克密理博,385585,17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor - Calbiochem


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