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品种反应性 主要应用 宿主 格式 抗体类型 H, M, R IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN325 描述 Anti-SAPAP3 Antibody Alternate Names - DLGAP3
- SAP90
- PSD-95-associated protein 3
- Disks large-associated protein 3
背景信息 SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist. 产品信息 格式 Affinity Purified 控制 - Rat brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. 应用 应用 This SAPAP3 antibody is validated for use in WB & IHC for the detection of the SAPAP3 protein. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SAPAP3 in mouse midbrain tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human SAPAP3. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes isoforms SAPAP3α and SAPAP3β. 品种反应性 HumanMouseRat Species Reactivity Note Demonstrated to react with Mouse and Rat. Predicted to react with Human based on immunogen design. 抗体类型 Polyclonal Antibody 基因符号 - DLGAP1
纯化方法 Antigen Affinity purified UniProt编号 - O95886
产品使用声明 质量保证 Evaluated by Western Blot in rat brain tissue lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected SAPAP3 in 15 µg/mL of rat brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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