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merck millipore,默克密理博,05-827,Anti-Glucocorticoid Receptor Antibody, clone FIGR
产品名称：Anti-Glucocorticoid Receptor Antibody, clone FIGR
产品型号：05-827
Detect Glucocorticoid Receptor with Anti-Glucocorticoid Receptor Antibody, clone FIGR (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.
merck millipore,默克密理博,05-827,Anti-Glucocorticoid Receptor Antibody, clone FIGR
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, Ht, M WB M Purified Monoclonal Antibody 描述 产品目录编号 05-827 品牌系列 Upstate
商名 - Upstate
描述 Anti-Glucocorticoid Receptor Antibody, clone FIGR 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Glucocorticoid Receptor with Anti-Glucocorticoid Receptor Antibody, clone FIGR (Mouse Monoclonal Antibody), that has been shown to work in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Native glucocorticoid receptor purified from rat liver 克隆 clone FIGR 宿主 Mouse 特异性 glucocorticoid receptor 同种型 IgG2b 品种反应性 RatHamsterMouse Species Reactivity Note Not Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000176
Entrez基因汇总 The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. 基因符号 - GR
- NR3C1
- GRL
- GCR
- GCCR
纯化方法 Protein G purfied UniProt编号 - P04150
UniProt汇总 FUNCTION: SwissProt: P04150 # Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).
SIZE: 777 amino acids; 85659 Da
SUBUNIT: Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding.
TISSUE SPECIFICITY: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
DOMAIN: SwissProt: P04150 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
PTM: Increased proteasome-mediated degradation in response to glucocorticoids. & Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser- 203-phosphorylated form is mainly cytoplasmic, and the Ser-211- phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211. & Sumoylated; this reduces transcription transactivation.
DISEASE: SwissProt: P04150 # Defects in NR3C1 are a cause of glucocorticoid resistance [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
MISCELLANEOUS: High constitutive expression of isoform beta by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation. & Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from L6, PC12, and 3T3/A31 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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