merck millipore,默克密理愽
  • merck millipore,默克密理博,385585,17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor - Calbiochem

  • merck millipore,默克密理博,385585,17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor - Calbiochem

    产品名称：17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor - Calbiochem
    产品型号：385585
    The 17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor controls the biological activity of 17β-Hydroxysteroid Dehydrogenase Type-3.

    merck millipore,默克密理博,385585,17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,385585,17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₂BrNO₃S₂
    描述
    概述 A cell-permeable benzylidine-thioxothiazolidinone compound that blocks the steroidogenesis of testosterone by directly inhibiting 17β-HSD3- (17β-hydroxysteroid dehydrogenase type 3) catalyzed, NADPH-dependent, reduction of Δ4-dione C17 ketone in a Δ4-dione- (4-androstene-3,17-dione) competitive, highly potent (IC50 = 0.6, 6.0, and 40 nM, respectively, against momoset, human, and mouse 17β-HSD3 activity in testes homogenate), and selective manner, displaying no activity against 17β-HSD1 and 17β-HSD2 activity. Poor pharmacokinetic properties limit its use to culture treatments and cell-free assays only.
    产品目录编号 385585
    品牌系列 Calbiochem®
    同义词 17β-HSD3 Inhibitor, 5-(3-Bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one
    参考
    参考 Harada, K., et al. 2012. Bioorg. Med. Chem. Lett. 22, 504.
    产品信息
    形式 Yellow solid
    Hill配方 C₁₇H₁₂BrNO₃S₂
    化学配方 C₁₇H₁₂BrNO₃S₂
    Molar Mass 422.3
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,385585,17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor - Calbiochem

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