merck millipore,默克密理愽
  • merck millipore,默克密理博,09-007,Anti-acetyl STAT5B (Lys694) Antibody

  • merck millipore,默克密理博,09-007,Anti-acetyl STAT5B (Lys694) Antibody

    产品名称：Anti-acetyl STAT5B (Lys694) Antibody
    产品型号：09-007
    Anti-acetyl STAT5B (Lys694) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl STAT5B (Lys694) also known as Signal transducer & activator of transcription 5B & has been validated in DB  More>>

    merck millipore,默克密理博,09-007,Anti-acetyl STAT5B (Lys694) Antibody

  • 产品介绍
  • merck millipore,默克密理博,09-007,Anti-acetyl STAT5B (Lys694) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 09-007
    描述 Anti-acetyl STAT5B (Lys694) Antibody
    Alternate Names
    • Signal transducer and activator of transcription 5B
    背景信息 STAT5B (signal transducers and activators of transcription 5b) controls the expression of early response genes and takes part in cytokine signaling. Studies have linked this protein to the inhibition of NFkappaB-mediated signaling. Additional studies have shown an association of STAT5B with regulation of lactation and growth, performance, and control of adipocyte function. Constitutively active STAT5B expression is often observed in a large number of leukemia’s and solid tumors.
    产品信息
    格式 Affinity Purified
    控制
    • Modified and non modified peptides of acetylated and non-acetylated STAT5B protein
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-acetyl STAT5B (Lys694) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl STAT5B (Lys694) also known as Signal transducer & activator of transcription 5B & has been validated in DB & WB.
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis: A representative lot was used by an independent laboratory in WB. (Ma, L., et al. (2010). Proc Natl Acad Sci U S A. 107(45):19314-19319.)
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to mouse STAT5B acetylated at Lys694.
    表位 Acetylated Lys694
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes STAT5B acetylated at Lys694.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rat based on 100% sequence homology. Predicted to react with Mouse based on immunogen design.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001107035
    基因符号
    • Stat5b
    修改
    • Acetylation
    纯化方法 Affinity purified
    UniProt编号
    • P42232
    UniProt汇总 FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

    SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member. Interacts with SOCS7 By similarity. Binds NR3C1 and NCOA1.

    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

    TISSUE SPECIFICITY: In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.

    DEVELOPMENTAL STAGE: Detected both in virgin mouse and after mammary gland involution. The level of STAT5A increases constantly during pregnancy, but decreases during lactation.

    PTM: Tyrosine phosphorylated.

    POLYMORPHISM: The polymorphism at position 327 in strain NOD reduces DNA-binding affinity.

    SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.

    Contains 1 SH2 domain.
    产品使用声明
    质量保证 Evaluated by Dot Blot in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.

    Dot Blot Analysis: 1 µg/mL of this antibody detected STAT5B in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,09-007,Anti-acetyl STAT5B (Lys694) Antibody

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