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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-705 Replaces MABE545 品牌系列 Upstate
商名 - Upstate
描述 Anti-LSD1/BHC110 Antibody Alternate Names - KDM1
产品信息 格式 Serum 应用 应用 Use Anti-LSD1/BHC110 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect LSD1/BHC110 also known as KDM1. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 47-66 (PAEV-GPGAVGERTPRKKEPP) of human BRAF-HDAC complex protein/Lysine-specific histone demethylase 1 (BHC110/LSD1). 宿主 Rabbit 特异性 Recognizes BHC110/LSD1 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_015013.2
Entrez基因汇总 This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternate splicing has been observed; however, not all transcript variants have been fully characterized. 基因符号 - BHC110
- AOF2
- LSD1
- KIAA0601
UniProt编号 - O60341
UniProt汇总 FUNCTION: SwissProt: O60341 # Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri- methylated 'Lys-4' of histone H3. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. May also demethylate 'Lys- 9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
COFACTOR: FAD.
SIZE: 852 amino acids; 92903 Da
SUBUNIT: Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitously expressed.
DOMAIN: SwissProt: O60341 The SWIRN domain may act as an anchor site for a histone tail.
SIMILARITY: Belongs to the flavin monoamine oxidase family. & Contains 1 SWIRM domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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