merck millipore,默克密理博,07-886,Anti-phospho-PKR (Thr451) Antibody

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merck millipore,默克密理博,07-886,Anti-phospho-PKR (Thr451) Antibody
产品名称：Anti-phospho-PKR (Thr451) Antibody
产品型号：07-886
This Anti-phospho-PKR (Thr451) Antibody is validated for use in WB for the detection of phospho-PKR (Thr451).

merck millipore,默克密理博,07-886,Anti-phospho-PKR (Thr451) Antibody

产品介绍

merck millipore,默克密理博,07-886,Anti-phospho-PKR (Thr451) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-886
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-PKR (Thr451) Antibody
Alternate Names	EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2), EIF2AK1, MGC126524, PKR, PRKR EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2) EIF2AK1 MGC126524 PKR

产品信息
格式	Affinity Purified
演示	100 μL of affinity purified rabbit polyclonal IgG in PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 0.5 mg/mL BSA (IgG, protease free) and 0.025% sodium azide and 50% glycerol.

应用
应用	This Anti-phospho-PKR (Thr451) Antibody is validated for use in WB for the detection of phospho-PKR (Thr451).
主要应用	Western Blotting

生物信息
免疫原品种	Peptide corresponding to amino acid region encompassing the human phospho-PKR (Thr451)
宿主	Rabbit
特异性	Recognizes phosphorylated PKR (Thr451)
同种型	IgG
品种反应性	MouseHuman
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_002759.1
基因符号	EIF2AK1 EIF2AK2 PRKR PKR MGC126524
修改	Phosphorylation
纯化方法	Immunoaffinity purified
UniProt编号	P19525
UniProt汇总	FUNCTION: SwissProt: P19525 # Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. SIZE: 551 amino acids; 62094 Da SUBUNIT: Homodimer. Interacts with STRBP (By similarity). Interacts with DNAJC3. Inhibited by direct interaction with viral proteins such as HCV E2, HCV NS5A and influenza A NS1. Activated by the interaction with HIV-1 Tat. PTM: Autophosphorylated on several Ser and Thr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. SIMILARITY: SwissProt: P19525 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. & Contains 2 DRBM (double-stranded RNA-binding) domains. & Contains 1 protein kinase domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.