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  • merck millipore,默克密理博,HSP5MAG-63K,MILLIPLEX MAP Human Sepsis Magnetic Bead Panel 5 - Immune Response Multiplex Assay

  • merck millipore,默克密理博,HSP5MAG-63K,MILLIPLEX MAP Human Sepsis Magnetic Bead Panel 5 - Immune Response Multiplex Assay

    产品名称：MILLIPLEX MAP Human Sepsis Magnetic Bead Panel 5 - Immune Response Multiplex Assay
    产品型号：HSP5MAG-63K
    The analytes available for this multiplex kit are: PRTN-3 and ELA-2.

    merck millipore,默克密理博,HSP5MAG-63K,MILLIPLEX MAP Human Sepsis Magnetic Bead Panel 5 - Immune Response Multiplex Assay

  • 产品介绍
  • merck millipore,默克密理博,HSP5MAG-63K,MILLIPLEX MAP Human Sepsis Magnetic Bead Panel 5 - Immune Response Multiplex Assay

    重要规格表

    可用的分析物 品种反应性 主要应用 检测方法
    ELA-2, PRTN-3HMplexLuminex xMAP
    描述
    产品目录编号 HSP5MAG-63K
    商名
    • MILLIPLEX
    描述 MILLIPLEX MAP Human Sepsis Magnetic Bead Panel 5 - Immune Response Multiplex Assay
    背景信息 Sepsis or SIRS (systemic inflammatory response syndrome) results from infection, whether bacterial, viral, fungal or parasitic. According to the CDC, sepsis is the second leading cause of death in non-coronary ICU patients in the U.S. This hyper-reaction to infection interrupts homeostasis through an uncontrolled inflammatory response, including glucocorticoids and catecholamines, mediators of the humoral immune response, as well as pro-inflammatory cytokines. Severe sepsis occurs when hypotension or hypoperfusion to one or more organs leads to organ dysfunction, which, in turn, can cause septic shock, multiple organ dysfunction syndrome (MODS) and death.

    Apoptosis plays a critical role in the development of severe sepsis and MODS. Studies involving critically ill patients have demonstrated that increased apoptosis of lymphoid organs and other organ tissues contributes to immune suppression, the body’s failure to respond to an antigen and organ dysfunction. The same pro-inflammatory cytokines and humoral mediators also contribute to the development of acquired immune defects. During sepsis, lymphocyte apoptosis can be initiated by the release of glucocorticoids and “death” cytokines. Understanding this has caused a shift in interest toward therapies aimed at inhibiting apoptosis and reversing immune suppression.
    产品信息
    检测方法 Luminex xMAP
    配置 Design your multiplex kit by choosing from 2 analytes.
    精度（%）
    • Intra-assay: < 10
    • Inter-assay: < 15
    板面类型 MAGNETIC Immune Response
    应用
    应用 The analytes available for this multiplex kit are: PRTN-3 and ELA-2.
    主要应用
    • Multiplexing
    应用说明 The preferred assay is an overnight assay (4ºC) requiring 25 ul of neat samples for Panel 4 and 25 uL of diluted sample (1:100 recommended) serum, plasma or tissue culture supernatants. Plasma is preferred over serum; when serum is used, it is recommended that serum be used throughout the study to maintain consistency.
    生物信息
    特异性 There was no or negligible cross-reactivity between the antibodies for the analytes in this panel.
    品种反应性 Human
    可用的分析物
    • ELA-2
    • PRTN-3
    准确度
    • 84% - 101%
    理化信息
    灵敏度
    • Refer to kit protocol for individual sensitivites.
    标准曲线范围
    • ELA-2: 0.002-10 ng/mL
    • PRTN-3: 0.012-50 ng/mL
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 96-well plate

    merck millipore,默克密理博,HSP5MAG-63K,MILLIPLEX MAP Human Sepsis Magnetic Bead Panel 5 - Immune Response Multiplex Assay

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