merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1651,Anti-phospho-β Catenin (Ser37) Antibody

  • merck millipore,默克密理博,07-1651,Anti-phospho-β Catenin (Ser37) Antibody

    产品名称：Anti-phospho-β Catenin (Ser37) Antibody
    产品型号：07-1651
    This Anti-phospho-β Catenin (Ser37) Antibody is validated for use in WB for the detection of phospho-β Catenin (Ser37).

    merck millipore,默克密理博,07-1651,Anti-phospho-β Catenin (Ser37) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1651,Anti-phospho-β Catenin (Ser37) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1651
    Replaces 04-1070
    描述 Anti-phospho-β Catenin (Ser37) Antibody
    Alternate Names
    • catenin beta-1
    • B Catenin (pSer37)
    • Beta-catenin
    • catenin (cadherin-associated protein), beta 1 (88kD)
    • catenin (cadherin-associated protein), beta 1, 88kDa
    背景信息 Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer. After phosphorylation, beta catenin is rapidly degraded into various fragments over time (Tesco G., et al. 1998. J. Biol. Chem. 273(51):33909-33914).
    产品信息
    格式 Affinity Purified
    控制
    • Calycullin/Okadoic acid treated and untreated HEK293 cell lysate.
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-phospho-β Catenin (Ser37) Antibody is validated for use in WB for the detection of phospho-β Catenin (Ser37).
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis: 1:500-1:1000 dilution from a representative lot detected Ser37 phosphorylated beta chain in Calyculin A/Okadoic acid treated HEK293 cell lysate.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Phospho-B Catenin (Ser37) near the N-terminus.
    浓缩 Please refer to lot specific datasheet.
    宿主 Rabbit
    品种反应性 Rat
    Species Reactivity Note Rat and Human. Predicted to react with Mouse, Zebrafish, Xenopus, Chicken based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001098210
    基因符号
    • CTNNB
    • CTNNB1
    修改
    • Phosphorylation
    纯化方法 Affinity Purfied
    UniProt编号
    • P35222
    产品使用声明
    质量保证 Evaluated by Western Blotting in Calyculin A and Okadaic acid treated L6 cell lysate.

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ser37 phosphorylated beta chain in 10 µg of Calyculin A and Okadaic acid treated L6 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-1651,Anti-phospho-β Catenin (Ser37) Antibody

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