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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Vrt, H IP Rb Purified Polyclonal Antibody 描述 产品目录编号 07-658 Replaces 04-399 品牌系列 Upstate
商名 - Upstate
描述 Anti-PI3 Kinase Antibody, p110α 产品信息 格式 Purified 应用 应用 This Anti-PI3 Kinase Antibody, p110α is validated for use in IP for the detection of PI3 Kinase. 主要应用 - Immunoprecipitation
应用说明 Western blot NOT recommended 生物信息 免疫原品种 KLH-conjugated, synthetic peptide (CTTKMDWIFHTIKQHALN) corresponding to amino acids 1052-1068 of human 110kDa PI3 Kinase, with an N-terminal cysteine added for conjugation purposes 宿主 Rabbit 特异性 PI3 Kinase 110kDa alpha catalytic subunit and co-immunoprecipitates the associated 85kDa regulatory subunit 同种型 IgG 品种反应性 VertebratesHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006218.2
Entrez基因汇总 Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. 基因符号 - p110-alpha
- PIK3CA
- MGC142163
- PI3K
- MGC142161
纯化方法 Protein A purfied UniProt编号 - P42336
UniProt汇总 FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1068 amino acids; 124284 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.产品使用声明 质量保证 routinely evaluated by immunoprecipitation on RIPA lysates from EGF-stimulated A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 stable 2 years at -20°C from date of shipment 包装信息 数量 200 µg
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