merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1383,Anti-Integrin α4 Antibody, clone HP2/1

  • merck millipore,默克密理博,MAB1383,Anti-Integrin α4 Antibody, clone HP2/1

    产品名称：Anti-Integrin α4 Antibody, clone HP2/1
    产品型号：MAB1383
    Detect Integrin α4 using this Anti-Integrin α4 Antibody, clone HP2/1 validated for use in FC, IP, IH.

    merck millipore,默克密理博,MAB1383,Anti-Integrin α4 Antibody, clone HP2/1

  • 产品介绍
  • merck millipore,默克密理博,MAB1383,Anti-Integrin α4 Antibody, clone HP2/1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, B, HIHC, FCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1383
    Replaces 04-1131
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α4 Antibody, clone HP2/1
    Alternate Names
    • CD49d
    产品信息
    格式 Purified
    演示 Purified immunoglobulin - Ig fraction. Liquid in Phosphate Buffered Saline, pH 7.4 with 0.1% Sodium Azide.
    应用
    应用 Detect Integrin α4 using this Anti-Integrin α4 Antibody, clone HP2/1 validated for use in FC, IP, IH.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    应用说明 Flow cytometry: 1μg/5 X 10E5 cells

    Immunohistology on frozen tissue sections

    Immunoprecipitation

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 JM leukemia line
    克隆 HP2/1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes the 80kDa alpha chain of VLA-4. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells. Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1.
    同种型 IgG1
    品种反应性 RatBovineHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000885.4
    Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
    基因符号
    • CD49d
    • ITGA4
    • MGC90518
    • VLA-4
    • IA4
    • CD49D
    UniProt编号
    • P13612
    UniProt汇总 FUNCTION: SwissProt: P13612 # Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
    SIZE: 1038 amino acids; 115333 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P13612 The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
    PTM: Phosphorylation on Ser-1027 inhibits PXN binding.
    SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20°C in undiluted aliquots. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1383,Anti-Integrin α4 Antibody, clone HP2/1

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