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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABF292 描述 Anti-ZC3H12A Antibody Alternate Names - Zinc finger CCCH domain-containing protein 12A
- Ribonuclease ZC3H12A
- MCP-induced protein 1
背景信息 Ribonuclease ZC3H12A, also known as MCP-induced protein 1 or Zinc finger CCCH domain-containing protein 12A, and encoded by the gene name ZC3H12A or MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation. ZC3H12A may be involved in host immunity and inflammatory diseases. It has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPγ. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-ZC3H12A Antibody detects level of ZC3H12A & has been published & validated for use in ZC3H12A. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the center region of human ZC3H12A. 表位 center region 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - MCPIP1
- ZC3H12A
- MCPIP
纯化方法 Antigen Affinity purified UniProt编号 - Q5D1E8
产品使用声明 质量保证 Evaluated by Western Blotting in Raji Cell lysate.
Western Blotting Analysis: 2 μg/mL of this antibody detected ZC3H12A in Raji Cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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