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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-505 品牌系列 Upstate
商名 - Upstate
描述 Anti-HDAC8 Antibody 产品信息 格式 Serum 演示 30% glycerol 应用 应用 Anti-HDAC8 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC8 also known as histone deacetylase 8 & has been tested in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to amino acids 305-377 of human HDAC8 宿主 Rabbit 特异性 HDAC8 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_018486
Entrez基因汇总 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. 基因符号 - HDACL1
- HDAC8
- HD8
- RPD3
纯化方法 Antiserum UniProt编号 - Q9BY41
UniProt汇总 FUNCTION: SwissProt: Q9BY41 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
SIZE: 377 amino acids; 41758 Da
SUBUNIT: Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3.
SUBCELLULAR LOCATION: Nucleus. Note=Excluded from the nucleoli.TISSUE SPECIFICITY: Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas.
SIMILARITY: SwissProt: Q9BY41 ## Belongs to the histone deacetylase family. Type 1 subfamily.
MISCELLANEOUS: Its activity is inhibited by trichostatin A (TSA) and butyrate, two well known histone deacetylase inhibitors.产品使用声明 质量保证 routinely evaluated by immunoblot in in a nuclear extract of mouse liver 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,MAB374,Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody, clone 6C5
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