merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL1313,Anti-CD11b Antibody, clone M1/70.15.1

  • merck millipore,默克密理博,CBL1313,Anti-CD11b Antibody, clone M1/70.15.1

    产品名称：Anti-CD11b Antibody, clone M1/70.15.1
    产品型号：CBL1313
    Anti-CD11b Antibody, clone M1/70.15.1 detects level of CD11b & has been published & validated for use in FC, IF & IP.

    merck millipore,默克密理博,CBL1313,Anti-CD11b Antibody, clone M1/70.15.1

  • 产品介绍
  • merck millipore,默克密理博,CBL1313,Anti-CD11b Antibody, clone M1/70.15.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MFCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL1313
    Replaces MAB1458
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-CD11b Antibody, clone M1/70.15.1
    Alternate Names
    • C3bi receptor
    • Integrin alphaM
    • Mac-1
    • Complement Receptor Type 3 alpha Subunit
    产品信息
    格式 Purified
    演示 The monoclonal is presented at 0.5mg/1 mL in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 Anti-CD11b Antibody, clone M1/70.15.1 detects level of CD11b & has been published & validated for use in FC, IF & IP.
    主要应用
    • Flow Cytometry
    不建议的应用
    • Immunohistochemistry (Paraffin)
    应用说明 Flow Cytometry 1:50-1:100

    Immunohistology on fresh frozen or acetone fixed tissues.

    Immunohistochemistry on paraffin embedded tissues fixed in PLP, methyl-carnoy, or 2% PFA; traditional 10% formalin fixation is problematic.

    Immunoprecipitation: use a rabbit anti-rat secondary for capture.

    Functional/blocking of C3bi binding to its receptor.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 B10 mouse spleen cells enriched with T cells
    克隆 M1/70.15.1
    宿主 Rat
    特异性 The antibody recognizes a differentiation antigen situated on mononuclear phagocytes and granulocytes. The expression of this antigen (Mac 1) increases during monocyte maturation.

    FUSION PARTNER: NS1/1.Ag4.1 mouse myeloma cell line
    同种型 IgG2b
    品种反应性 Mouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000632.3
    Entrez基因汇总 This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable
    基因符号
    • MGC117044
    • ITGAM
    • MO1A
    • CD11b
    • MAC1A
    • CD11B
    • MAC-1
    • CR3A
    UniProt编号
    • P11215
    UniProt汇总 FUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
    SIZE: 1152 amino acids; 127179 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.
    DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 500 µg

    merck millipore,默克密理博,CBL1313,Anti-CD11b Antibody, clone M1/70.15.1

上一件merck millipore产品：merck millipore,默克密理博,MAB374,Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody, clone 6C5
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