merck millipore,默克密理愽
  • merck millipore,默克密理博,05-897,Anti-HDAC9 Antibody, clone LH/JC2

  • merck millipore,默克密理博,05-897,Anti-HDAC9 Antibody, clone LH/JC2

    产品名称：Anti-HDAC9 Antibody, clone LH/JC2
    产品型号：05-897
    Detect HDAC9 also known as histone deacetylase 9 with Anti-HDAC9 Antibody, clone LH/JC2 (Rat Monoclonal Antibody), that has been demonstrated to work in WB, ICC.

    merck millipore,默克密理博,05-897,Anti-HDAC9 Antibody, clone LH/JC2

  • 产品介绍
  • merck millipore,默克密理博,05-897,Anti-HDAC9 Antibody, clone LH/JC2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBRPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-897
    Replaces MABE562
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-HDAC9 Antibody, clone LH/JC2
    产品信息
    格式 Purified
    应用
    应用 Detect HDAC9 also known as histone deacetylase 9 with Anti-HDAC9 Antibody, clone LH/JC2 (Rat Monoclonal Antibody), that has been demonstrated to work in WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 synthetic peptide corresponding to amino acids 1046-1060 of human HDAC9 isoform 5
    克隆 clone LH/JC2
    宿主 Rat
    特异性 HDAC9
    同种型 IgM
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_178425.2
    • NM_014707.1
    • NM_058176.2
    • NM_058177.2
    • NM_178423.1
    Entrez基因汇总 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
    基因符号
    • HDAC7
    • HDAC9
    • HDAC9FL
    • MITR
    • HD9
    • HDRP
    • HDAC9B
    • KIAA0744
    • DKFZp779K1053
    • HDAC
    • HD7B
    • HD7
    • HDAC7B
    纯化方法 Protein G purfied
    UniProt编号
    • Q9UKV0
    UniProt汇总 FUNCTION: SwissProt: Q9UKV0 # Isoform 3, called MITR/HDRP, lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription via HDAC1 recruitment to c-Jun promoter.
    SIZE: 1011 amino acids; 111297 Da
    SUBUNIT: Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3 (By similarity). Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6.
    SUBCELLULAR LOCATION: Nucleus (By similarity).
    TISSUE SPECIFICITY: Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
    PTM: Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3- binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. & Sumoylated.
    DISEASE: SwissProt: Q9UKV0 # A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly [MIM:604229]. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
    SIMILARITY: SwissProt: Q9UKV0 ## Belongs to the histone deacetylase family. Type 2 subfamily.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot with RIPA lysates from HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-897,Anti-HDAC9 Antibody, clone LH/JC2

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