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品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-502 品牌系列 Upstate
商名 - Upstate
描述 Anti-p67-phox (mouse) Antibody Alternate Names - neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
- 67 kDa neutrophil oxidase factor
- NADPH oxidase activator 2
- Neutrophil NADPH oxidase factor 2
- chronic granulomatous disease, autosomal 2
- neutrophil cytosol factor 2
- neutrophil cytosolic factor 2
- neutrophil cytosolic factor 2
- neutrophil cytosolic factor 2 (65kD
背景信息 Activation of NADPH-oxidase dependent superoxide generation requires the participation of several cytosolic factors including p47phox, p67phox, p40phox and Rac (1 or 2). In the resting cell, p47phox, p67phox, and p40phox form a large molecular weight complex which can be recovered from the cytosolic fraction. Activation of the NADPH oxidase is initiated by the assembly of p47phox, p67phox, and Rac with cytochrome b558 in a 1:1:1:1 complex in the plasma membrane. p47phox, p67phox, and Rac exhibit cooperative binding, since increasing the concentration of any one component lowers the EC50 of the other components. A great deal of current research involves understanding the protein protein interactions, and how these change with the activation state. 产品信息 格式 Purified 控制 - Rat brain tissue, RAW 264.7 cell lysate.
演示 Purified rabbit polyclonal IgG in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4. 应用 应用 Detect p67-phox (mouse) using this Anti-p67-phox (mouse) Antibody validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry: This antibody has been demonstrated by an independent laboratory to detect p67-phox in male rat brain cortex tissue. 生物信息 免疫原品种 KLH-conjugated, synthetic peptides corresponding to the first 15 amino acids from the N-terminal and the last 15 amino acids on the C-terminal of mouse p67-phox. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes p67-phox, MW ~67 kDa. 同种型 IgG 品种反应性 RatMouse Species Reactivity Note Mouse and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000424
Entrez基因汇总 This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease. 基因符号 - P67-PHOX
- NCF2
- NCF-2
- NOXA2
- p67phox
- p67-phox
纯化方法 Protein A purfied UniProt编号 - P19878
UniProt汇总 FUNCTION: SwissProt: P19878 # NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
SIZE: 526 amino acids; 59762 Da
SUBUNIT: Interacts with SYTL1 and RAC1. May interact with NOXO1.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P19878 # Defects in NCF2 are a cause of autosomal recessive chronic granulomatous disease (AR-CGD) [MIM:233710]; also known as autosomal cytochrome-b-positive chronic granulomatous disease. It causes recurrent infection by catalase-positive organisms.
SIMILARITY: SwissProt: P19878 ## Contains 1 OPR domain. & Contains 2 SH3 domains. & Contains 3 TPR repeats.产品使用声明 质量保证 Evaluated by western blot in RIPA lysates from RAW 264.7 cells.
Western Blot Analysis: 0.5-2.0 µg/mL of this antibody detected p67-phox in RIPA lysates from RAW 264.7 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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