merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB13415,Anti-MMP-9 Antibody, clone GE-213

  • merck millipore,默克密理博,MAB13415,Anti-MMP-9 Antibody, clone GE-213

    产品名称：Anti-MMP-9 Antibody, clone GE-213
    产品型号：MAB13415
    Anti-MMP-9 Antibody, clone GE-213 is an antibody against MMP-9 for use in IP, WB & IH.

    merck millipore,默克密理博,MAB13415,Anti-MMP-9 Antibody, clone GE-213

  • 产品介绍
  • merck millipore,默克密理博,MAB13415,Anti-MMP-9 Antibody, clone GE-213

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB13415
    Replaces 04-1150
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MMP-9 Antibody, clone GE-213
    Alternate Names
    • 92 kDa Type IV Collagenase
    • Gelatinase B
    产品信息
    格式 Purified
    控制
    • POSITIVE CONTROL: Cytotrophoblastic columns, the endothelial and fibroblastic stromal cells of villi, and the large decidualized cells of decidual membrane in placenta (Hurskainen et al., 1996). Macrophages in arteries (Nikkari et al., 1996), and fibroblast, endothelial, and tumor cells in breast carcinomas (Soini et al., 1994; Visscher et al., 1994). Conditioned serum-free medium from (dexamethasone-treated) human fibrosarcoma HT-10801 (Nikkari et al., 1996) or endothelial HUVEC4 (Schnaper et al., 1993) cells.
    演示 Purified from ascites fluid by Protein G chromatography. Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
    应用
    应用 Anti-MMP-9 Antibody, clone GE-213 is an antibody against MMP-9 for use in IP, WB & IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western Blotting (non-reducing; Nikkari et al., 1996) (Use Ab at 1μg/mL for 2hrs at RT)

    Immunohistochemistry (Acetone-fixed frozen; Hurskainen, 1996): 1:100 for 30 minutes at room temperature

    Immunoprecipitation: 2-5 μg/mg protein lysate (use protein G to precipitate immune complex).

    Inhibition of MMP-9 Activity: 2-4μg/mL (Visscher, 1994)



    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified human gelatinase B.
    克隆 GE-213
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Under non-reducing conditions, it recognizes proteins of 92 kDa and 86 kDa which are identified as pro (latent) and active forms of matrix metalloproteinase-9 (MMP-9; also known as 92 kDa and collagenase IV or gelatinase B) of human MMP-9. MAB13415 reacts with the complex (~200 kDa) of MMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1; Nikkari et al., 1996). It shows no cross-reaction with pro and active forms of MMP-2 (Nikkari et al., 1996). Clone GE-213 also shows very low reactivity to mouse MMP-9 proteins by western blot, but at high enough antibody and antigen concentrations some detection is possible. Mouse immunhistochemistry is untested. Cellular Localization: Peripheral cytoplasmic.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004994.2
    Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
    基因符号
    • 82 kDa matrix metalloproteinase-9].
    • MMP9
    • MMP-9
    • GELB
    • CLG4B
    • EC 3.4.24.35 [Contains: 67 kDa matrix metalloproteinase-9
    UniProt编号
    • P14780
    UniProt汇总 FUNCTION: SwissProt: P14780 # May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond.
    COFACTOR: Binds 2 zinc ions per subunit. & Binds 3 calcium ions per subunit.
    SIZE: 707 amino acids; 78427 Da
    SUBUNIT: Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.
    TISSUE SPECIFICITY: Produced by normal alveolar macrophages and granulocytes.
    DOMAIN: SwissProt: P14780 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    PTM: Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
    SIMILARITY: Belongs to the peptidase M10A family. & Contains 3 fibronectin type-II domains. & Contains 4 hemopexin-like domains.
    MISCELLANEOUS: In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Manufactured by Daiichi Fine Chemical Co., Ltd
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.

    During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB13415,Anti-MMP-9 Antibody, clone GE-213

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