merck millipore,默克密理博,506101,p21-Activated Kinase Inhibitor, PAK18

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Merck Millipore 默克密理愽

merck millipore,默克密理博,506101,p21-Activated Kinase Inhibitor, PAK18 - Calbiochem

经验配方
C₁₄₆H₂₅₄N₅₈O₃₇

描述
概述	A PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).
产品目录编号	506101
品牌系列	Calbiochem®
同义词	H₂N-RKKRRQRRR~G~PPVIAPRPEHTKSVYTRS-CO₂H, PAK Inhibitor I

参考
参考	Zhao, L., et al. 2006. Nat. Neurosci. 9, 234. Maruta, H., et al. 2002. Methods Mol. Biol. 189, 75.

产品信息
具有ATP竞争性	N
形式	Lyophilized
配方	Supplied as trifluoroacetate salt
Hill配方	C₁₄₆H₂₅₄N₅₈O₃₇
化学配方	C₁₄₆H₂₅₄N₅₈O₃₇
Molar Mass	3413.9
吸湿	Hygroscopic
肽序列	H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH
可逆	N

生物信息
主靶	PAK (p21-activated kinase)
纯度	≥97% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO or H₂O
肽序列	H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,506101,p21-Activated Kinase Inhibitor, PAK18 - Calbiochem

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