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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 CBL158 Replaces CBL514 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin β2 [CD18] Antibody Alternate Names - CD18
产品信息 格式 Purified 演示 The monoclonal is presented in phosphate buffered saline containing 15mM sodium azide, pH 7.4. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Anti-Integrin β2 [CD18] Antibody detects level of Integrin β2 [CD18] & has been published & validated for use in FC, WB, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
- Western Blotting
应用说明 Immunohistochemistry: Identification of CD18+ leucocytes on cryostat sections
Function Blocking: Studies of cell-cell and cell-matrix adhesion, this antibody will block cell-cell interaction
Flow Cytometry
Western Blot
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Leucocytes from an LGL - type leukaemia 克隆 MEM 48 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes the CD18 molecule, a 95 kDa integrin molecule (beta 2 integrin) that forms the common beta chain of the CD11/CD18 heterodimer integrins which are expressed on all leucocytes. The beta2 integrin is the ICAM 1 receptor
FUSION PARTNER:
Sp 2/0 - Ag 14 myeloma cell line同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000211.2
Entrez基因汇总 The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. 基因符号 - MAC-1
- ITGB2
- MFI7
- LAD
- CD18
- MF17
- LCAMB
- LFA-1
UniProt编号 - P05107
UniProt汇总 FUNCTION: SwissProt: P05107 # Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1.
SIZE: 769 amino acids; 84782 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.DISEASE:SwissProt: P05107 # Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
SIMILARITY: SwissProt: P05107 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2o-8oC for up to 12 months from date of receipt. For long term storage aliquot antibody into small volumes and store at -20°C for up to one year. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,506101,p21-Activated Kinase Inhibitor, PAK18 - Calbiochem
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