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merck millipore,默克密理博,MAB3732,Anti-c-jun Antibody, clone 6A6.2
产品名称：Anti-c-jun Antibody, clone 6A6.2
产品型号：MAB3732
Use Anti-c-jun Antibody, clone 6A6.2 (Mouse Monoclonal Antibody) validated in WB to detect c-jun also known as JNK1 alpha protein kinase, JNK1 beta protein kinase.
merck millipore,默克密理博,MAB3732,Anti-c-jun Antibody, clone 6A6.2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3732 Replaces 04-210 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-c-jun Antibody, clone 6A6.2 Alternate Names - AP-1
- Activator Protein 1
背景信息 c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun. 产品信息 格式 Purified 控制 - NIH-3T3 cells
演示 Protein A purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide 应用 应用 Use Anti-c-jun Antibody, clone 6A6.2 (Mouse Monoclonal Antibody) validated in WB to detect c-jun also known as JNK1 alpha protein kinase, JNK1 beta protein kinase. 主要应用 - Western Blotting
应用说明 Western blot: (1-2 ug/mL)
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant c-Jun GST fusion protein 克隆 6A6.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes c-Jun, the cellular homolog of the avian sarcoma virus 17 oncogene, v-jun. It is a member of the transcriptional complex called AP1, a group of related dimeric basic region-leucine zipper proteins belonging to the Jun, Fos, Maf, and ATF subfamilies. c-Jun is activated by phosphorylation by c-Jun-N-terminal kinases (JNKs). 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002228.3
Entrez基因汇总 This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. 基因符号 - c-Jun
- JUN
- AP1
- p39
UniProt编号 - P05412
UniProt汇总 FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
SIZE: 331 amino acids; 35676 Da
SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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