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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-418 Replaces 04-368 品牌系列 Upstate
商名 - Upstate
描述 Anti-IRAK4 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-IRAK4 Antibody detects level of IRAK4 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 436-459 of human IRAK4 宿主 Rabbit 特异性 IRAK4 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_016123
Entrez基因汇总 Interleukin-1 receptor (see IL1R; MIM 147810)-associated kinases (e.g., IRAK1; MIM 300283) are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.[supplied by OMIM] 基因符号 - IPD1
- IRAK4
- REN64
- NY-REN-64
- IRAK-4
- LOC51135
纯化方法 Protein A purfied UniProt编号 - Q9NWZ3
UniProt汇总 FUNCTION: SwissProt: Q9NWZ3 # Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.
COFACTOR: Magnesium.
SIZE: 460 amino acids; 51530 Da
SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.
DISEASE: SwissProt: Q9NWZ3 # Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. & Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
SIMILARITY: SwissProt: Q9NWZ3 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
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