merck millipore,默克密理博,04-377,Anti-MEK2 NT Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-377,Anti-MEK2 NT Antibody, rabbit monoclonal
产品名称：Anti-MEK2 NT Antibody, rabbit monoclonal
产品型号：04-377
Anti-MEK2 NT Antibody, Rabbit detects level of MEK2 NT & has been published & validated for use in FC, IC, IH(P), IP & WB.

merck millipore,默克密理博,04-377,Anti-MEK2 NT Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-377,Anti-MEK2 NT Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H	WB, FC, ICC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-377
品牌系列	Upstate
商名	Upstate
描述	Anti-MEK2 NT Antibody, rabbit monoclonal
Alternate Names	MAP2K2, MAPKK2, MKK2, PRKMK2 MAP2K2 MAPKK2 MKK2

产品信息
格式	Purified
演示	In 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.

应用
应用	Anti-MEK2 NT Antibody, Rabbit detects level of MEK2 NT & has been published & validated for use in FC, IC, IH(P), IP & WB.
主要应用	Western Blotting Flow Cytometry Immunocytochemistry
应用说明	Suggested dilutions: Immunoblot Analysis: 1:10,000 Immunoprecipitation: 1:100 Flow Cytometry: 1:40 Immunohistochemistry: A 1:250-1:500 Immunfluorescence Staining: 1:250-1:500

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the N-terminal region of human MEK2.
宿主	Rabbit
特异性	Recognizes the N-terminal domain of MEK2.
同种型	IgG
品种反应性	RatHuman
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_030662.2
Entrez基因汇总	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
基因符号	MKK2 MAP2K2 MEK2 PRKMK2 MAPKK2
纯化方法	Serum
UniProt编号	P36507
UniProt汇总	FUNCTION: SwissProt: P36507 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). SIZE: 400 amino acids; 44424 Da SUBUNIT: Interacts with MORG1 (By similarity). PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). DISEASE: SwissProt: P36507 # Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. SIMILARITY: SwissProt: P36507 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.