merck millipore,默克密理愽
  • merck millipore,默克密理博,07-276,Anti-PDGFRα Antibody

  • merck millipore,默克密理博,07-276,Anti-PDGFRα Antibody

    产品名称：Anti-PDGFRα Antibody
    产品型号：07-276
    Detect PDGFRα using this Anti-PDGFRα Antibody validated for use in IP & WB.

    merck millipore,默克密理博,07-276,Anti-PDGFRα Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-276,Anti-PDGFRα Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-276
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-PDGFRα Antibody
    背景信息 Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue
    演示 Protein A Purified immunoglobulin in 0.14 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
    应用
    应用 Detect PDGFRα using this Anti-PDGFRα Antibody validated for use in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to amino acids 1035-1053 (C-GKRNRHSSQTSEESAIETG) of human PDGF Receptor α
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes PDGF Receptor alpha.
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_011058
    Entrez基因汇总 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
    基因符号
    • CD140A
    • PDGFRA
    • CD140a
    • PDGF-R-alpha
    • MGC74795
    • PDGFR2
    • Rhe-PDGFRA
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P16234
    UniProt汇总 FUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    SIZE: 1089 amino acids; 122670 Da
    SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
    SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on 3T3/NIH cell lysate
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,07-276,Anti-PDGFRα Antibody

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