merck millipore,默克密理愽
  • merck millipore,默克密理博,361569,GSK-3beta Inhibitor XXVI - Calbiochem

  • merck millipore,默克密理博,361569,GSK-3beta Inhibitor XXVI - Calbiochem

    产品名称：GSK-3beta Inhibitor XXVI - Calbiochem
    产品型号：361569
    The GSK-3β Inhibitor XXVI controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,361569,GSK-3beta Inhibitor XXVI - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,361569,GSK-3beta Inhibitor XXVI - Calbiochem

    重要规格表

    经验配方
    C₂₁H₁₈N₄O
    描述
    概述 A cell-permeable, pyrazolone GSK-3β inhibitor (IC50 = 34 nM, in an enzymatic assay) that is highly selective among a panel of 40 kinases that have been profiled with more than 50 fold selectivity. It exhibits no off-target activity against a panel of 44 human and rodent CNS receptors, channels, and transporters except for some modest activity toward 5HT1a. It demonstrates neuroprotective activity of neurons in an oxidative stress model induced by homocysteic acid (HCA) from 1–20 µM, without observable cytotoxicity, and is superior to SB-216763 Cat. No. 361566) at 5 µM in cell micrographs. In addition, it is shown to attenuate locomotor activity in an chlordiazepoxide/amphetamine-induced hyperactivity mice model in vivo at 150 mg/kg.
    产品目录编号 361569
    品牌系列 Calbiochem®
    参考
    参考 Chen, W., et al. 2011. ChemMedChem 6, 1587.
    产品信息
    形式 White solid
    Hill配方 C₂₁H₁₈N₄O
    化学配方 C₂₁H₁₈N₄O
    Molar Mass 342.39
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,361569,GSK-3beta Inhibitor XXVI - Calbiochem

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