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merck millipore,默克密理博,412400,IQ-1 - CAS 331001-62-8 - Calbiochem
产品名称:IQ-1 - CAS 331001-62-8 - Calbiochem
产品型号:412400
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.
merck millipore,默克密理博,412400,IQ-1 - CAS 331001-62-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₂₂N₄O₂ 331001-62-8 描述 概述 A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum. 产品目录编号 412400 品牌系列 Calbiochem®
同义词 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide, Wnt Pathway Activator III 参考 参考 Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 5668. 产品信息 CAS号 331001-62-8 形式 Orange solid Hill配方 C₂₁H₂₂N₄O₂ 化学配方 C₂₁H₂₂N₄O₂ Molar Mass 362.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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